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Psychedelic drugs a new erainpsychiatry? PMC A detailed analysis of the receptor binding profile for BOL, along with its functional effects, might shed light on the basis for the therapeutic effects of BOL against cluster headaches. The rabbit has not been widely used as an animal model to study the effects of psychedelics, but a number of experiments in this species have been carried out over the past decade, primarily in the laboratory of the late John A. Harvey. They found that daily injections of the 5-HT2A agonists DOI, LSD, and the antagonist 2-bromo-lysergic acid-N,N-diethylamide led to decreased cortical 5-HT2A receptor density but had no effect on density of cortical 5-HT2C receptors. At low doses of LSD (e.g., μg), sensory and cognitive processes may be distorted and altered but the user generally remains aware that the effects are attributable to having ingested the drug. For the purposes of clinical investigations, such doses allow the use of various questionnaires, inst